Meddle means to get involved in something that is not your business. It often has a negative meaning because it can cause problems or annoy people.
Don't meddle in my private life.
She meddled with her friend's work again.
This meaning means to touch or change something carefully or carelessly. Usually, meddling like this can cause problems or break something.
Don't meddle with the computer settings.
He meddled inside the machine and it broke.
Meddle here means to get involved in matters that do not concern you, especially personal or private issues. People do not like it when others meddle in their affairs.
He always meddles in his sister's problems.
Stop meddling and mind your own business.
This use means to interfere in events or situations where your influence is not wanted, often creating unfair results or problems for others.
The government should not meddle in the free market.
She meddled in the negotiations unfairly.
In this meaning, meddle means to mix things together, often causing a change in their usual state. This use is less common and usually figurative.
Don't meddle colors when painting.
He meddled ingredients for a new recipe.